Health

Progress in treatment is possible with the discovery of the main causes of liver failure

Israel: Experts have discovered the secret of complete liver failure at the cellular level and by stopping this process, patients can be saved from death.

Liver disease worsens rapidly and 80% of conditions result in death. This is a major problem in Western countries as well, and sometimes excessive use of paracetamol can lead to liver damage.

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Now, Iran Eleanor and Iduvamit, professors at the Weizmann Institute of Science, have seen in mice that three subtypes of cells in the liver combine to make the liver fail. In this process, the intestinal bacteria themselves also send signals to the diseased cells. Now that we understand this process, if we can block the signal or eliminate certain intestinal micro environment, it can avert death and give patients some time.

In the process, experts looked at rat liver cells before and after the disease and also noted the cells of human patients themselves. There was a striking resemblance between the two. Then the experts stopped the specific signals in the mice suffering from liver dysfunction, then their condition improved and the condition of the liver also started to improve.

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Of the many liver cells, however, identifying those with liver failure was a difficult one. A complete mapping of all the cells of the liver of the first mice was made and especially liver diseases and dysfunctions were noted. Thus, 49 subtypes of cells emerged and finally three types of cells were identified. These cells also secrete a lot of moisture.

On the other hand, the scientists also found out the pathway of the signal coming from the intestines and then selectively eliminated the microbes that were emitting such signals. Soon after, the diseased rats recovered and lived longer than the rest of the rats.

If not today, then tomorrow this method can be tried on humans to prevent immediate liver failure.

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