Scientists have for the first time identified the location of the body that may be the epicenter of the new Novel Coronavirus disease Code 19.In fact, two types of nasal cells form the initial entry point for the disease.
Cells called goblets and celiacs have high levels of code 19 entry proteins, which allow the virus to enter other cells.
The discovery was made by the Wellcome Singer Institute in the UK, the University Medical Center in Groningen in the Netherlands, the University of C d’Azur in France, CNRS, NICE and others, which helps explain why the disease spreads so fast. Has been
The study, published in the journal Nature Medicine, is the result of an international effort to use human cell data to understand infections and infections.
The study found that cells in the eye and a few other organs also become the center of the virus’s entry protein, while researchers also explained how an entry protein can be regulated and possible treatment targets.
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The new novice corona virus affects the lungs and respiratory tract, and patients show flu-like symptoms such as fever, cough, and sore throat, while many people show no symptoms but still carry the virus. Move.
The worst cases are pneumonia, which can lead to death.
The virus is thought to be spread by particles emitted from the mouth or nose during sneezing and coughing and is easily spread to the affected areas.
Scientists around the world are trying to understand how the virus spreads to prevent it from spreading and to develop a vaccine.
Although it was previously known that SARS-2 virus, which causes code 19, infects cells in the same way that SARS virus did in 2003, specific cells in the nose were not previously identified.
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To find out, the researchers analyzed the Human Cell Atlas data set and looked at more than 20 healthy people’s tissues.
These included cells from the lungs, the cavity, the eyes, the stomach, the heart, the kidneys and the liver, and scientists looked at which two of the virus’s main entry proteins help enter the disease.
The researchers said: “We discovered that the receptor protein S2 and TMPRSS2 stimulate the entry protein of SARS CoV2 to different organ cells, including the cells inside the nose.” ۔
When analyzed further, the researchers found that the mucus-producing goblet and ciliated cells contained the highest amounts of the proteins of the Code 19 virus, which may have been the primary source of infection for the virus.
The researchers said that this is the first time that these specific nasal cells have been linked to code 19 and that several elements play a role in the transmission of the virus, but our findings show that the location of these cells is very fast. Helps to spread.
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The virus’s two entries, S2 and TMPRSS2, were also detected in the cornea and intestinal cells, suggesting another possible route of the virus from the eye and tear ducts.
When cells are damaged by infection, a number of immune genes are activated, and this study found that the production of the S2 receptor in nasal cells changes when the immune genes are activated.
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The researchers said that this information would help in understanding the spread of corona virus and it is important to know what kind of cells play a role in the transmission of the virus, which could lead to possible therapies. It will be possible to reduce the rate of spread.